Image of Slobodan Praljak in the act of drinking a vial of liquid during his appeals hearing at The Hague on November 29, 2017.
It has now been reported by Dutch officials that Slobodan Praljak committed suicide by drinking cyanide.
What is cyanide?
Cyanide, also known as hydrocyanic acid, has a molecular formula HCN and its molecular weight is 27.03 g/mol. HCN’s boiling point is 25.6°C (78.1°F). Hydrogen cyanide was first isolated from the pigment Prussian blue; hence another alternative name is prussic acid. In the 1800s, cyanide was given its modern name from the English word cyan, which means a shade of blue. Hydrogen cyanide and its potassium and sodium salts have been used as fumigants, insecticides, metal polishes, and in gold/silver electroplating solutions. Cyanide vapor can be detected by a characteristic almond odor, but it is estimated that up to approximately 50% of the human population cannot detect this odor due to a recessive genetic trait. Cyanide can be found in trace levels in the human body as a result of normal metabolic processes, as well as from eating a diet high in cyanogenic foodstuffs (e.g. apples, apricots, bitter almonds, and cherries) and smoking cigarettes.
Chemical structure of Hydrogen Cyanide
Structure drawn by Kevin G. Shanks (2017)
What does cyanide do to the body?
Cyanide inhibits cellular respiration by binding to the iron atom in the cytochrome c oxidase enzyme, an enzyme involved in the last step of the mitochondrial electron transport chain. Normally, during this step, molecular oxygen is converted into water. This inhibition causes oxidative phosphorylation to halt and the Kreb’s cycle is disrupted. Adenosine triphosphate (ATP) cannot be produced by the mitochondria. Pyruvic acid, formed during glycolysis, accumulates and is modified anaerobically to lactic acid. Lactic acid buildup causes metabolic acidosis. Oxygen also builds up in tissue and alters the gradient for oxygen release from hemoglobin, which produces cellular hypoxia.
The onset of symptoms of cyanide poisoning is dependent on the route of exposure/administration. Hydrogen cyanide vapor is rapidly absorbed through inhalation. Potassium and sodium cyanide salts are more easily absorbed via oral ingestion, but are absorbed at lower rates and if ingested orally, they are converted to hydrogen cyanide via gastric acids. The lethal dose of hydrogen cyanide has been estimated to be 100 mg while sodium/potassium cyanide’s lethal dose has been estimated to be 200-300 mg.
Acute intoxication symptoms of cyanide poisoning are central nervous system stimulation, headache, dizziness, tachycardia, shortness of breath, rapid breathing, and vomiting. Other symptoms that may occur after initial intoxication include seizure, bradycardia, hypotension, coma, and cardiac arrest. Chronic administration of cyanide can lead to abnormalities of vitamin B12, folate, and thyroid function as well as severe longer-term neurological issues.
What does the body do to cyanide?
Cyanide is biotransformed to thiocyanate by the hepatic enzymes rhodanese and beta-mercaptopyruvate-cyanide sulfurtransferase. Thiocyanate is then excreted into the urine. Other metabolic pathways include trapping of cyanide by hydroxocobalamin via formation of vitamin B12, oxidation to formic acid and carbon dioxide, and pulmonary excretion of unchanged substance. The elimination half-life of cyanide in whole blood is reported as 0.7-2.1 hours. Volume of distribution is 0.4 L/kg.
Has it been used as a historical poison?
Because of its ease of use and toxicity, cyanide has appeared throughout history regularly as a poison, in warfare, suicides, and homicides. Some of the most well-known modern cases are:
It is rumored that cyanide played a role in Grigori Rasputin’s assassination in 1916. He was allegedly given cyanide-laced cakes and Madeira wine.
Hydrogen cyanide, as the pesticide Zyklon B, was used in gas chambers to murder people in the Nazi concentration camps during World War II.
In the 1940s, Erwin Rommel, Eva Braun, and Heinrich Himmler all committed suicide by cyanide liquid ingestion. The six children of Joseph Goebbels were murdered by being injected with morphine by Helmut Kunz, an SS dentist, and administered cyanide Ludwig Stumpfegger, Adolf Hitler’s personal doctor.
In 1974, Ronald Clark O’Bryan gave potassium cyanide laced Pixie Stix to his son, daughter, and three other children. The son ate the candy, while none of the other children did. The boy died. During the police investigation it was determined that the boy had a life insurance policy on him worth a very large amount of money. The father was convicted of murder in 1975 and was executed via lethal injection in 1984.
In 1978, in Jonestown, Guyana, 907 people died in a mass suicide event lead by Jim Jones. Cyanide, alongside diazepam, chloral hydrate, and promethazine, was consumed via a grape flavored beverage.
In 1982, seven people died from a series of drug tampering cases in Chicago, Illinois. Tylenol brand acetaminophen had been laced with potassium cyanide by an unknown person. Several more deaths occurred in copycat crimes. No one was ever convicted of these homicides.
In 1988, Stella Nickel was convicted of murdering her husband and another woman with cyanide-laced Excedrin tablets. She received a 90 year prison sentence.
Cyanide has also been used in capital punishment in the United States, with the last gas chamber execution via cyanide occurring in Arizona in 1999. It still remains an option for capital punishment in six states.
In 2012, Wall Street trader Michael Marin consumed a cyanide tablet while in the courtroom shortly after a guilty verdict for arson was rendered.
In 2015, John McLemore committed suicide using potassium cyanide. He was currently recording a narrative for the investigative journalism podcast S-Town.
Cyanide is a rapidly acting substance that causes death via disruption of cellular respiration and results in hypoxia and cardiac arrest. It is found as hydrogen cyanide or as potassium or sodium salts. It has been effectively used throughout history as an agent to murder people and has been implicated in suicides
Bosnian war criminal dies after swallowing poison in court. CNN. November 30, 2017. http://www.cnn.com/2017/11/29/europe/slobodan-praljak-hague-sentencing/index.html
Slobodan Praljak died after taking cyanide in court. Al Jazeera. December 2, 2017. http://www.aljazeera.com/news/2017/12/slobodan-praljak-died-cyanide-court-171202171937067.html
https://www.om.nl/actueel/nieuwsberichten/@101280/voorlopige/. Translated from Dutch to English via Google Translate. 12/03/2017.
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Poisoned, shot, and beaten: why cyanide along may have failed to kill Rasputin. The Guardian. January 13, 2017. https://www.theguardian.com/science/blog/2017/jan/13/poisoned-shot-and-beaten-why-cyanide-may-have-failed-to-kill-rasputin
The Holocaust: A Learning Site for Students, United States Holocaust Memorial Museum. https://www.ushmm.org/outreach/en/article.php?ModuleId=10007714
Candy Man’s legacy still haunting today. Chron. October 30, 2003. http://www.chron.com/neighborhood/article/Candy-Man-s-legacy-still-haunting-today-9774087.php
Jones plotted cyanide deaths years before Jonestown. CNN. November 12, 2008. http://www.cnn.com/2008/US/11/12/jonestown.cyanide/index.html
How the Tylenol murders of 1982 changed the way we consume medication. PBS. September 24, 2014. https://www.pbs.org/newshour/health/tylenol-murders-1982
Bitter Pill: A Wife on Trial. CBS News: 48 Hours, 2001. https://www.cbsnews.com/news/bitter-pill-a-wife-on-trial/
Michael Marin, former Wall Street trader, took cyanide after arson conviction, says autopsy. CBS News. July 27, 2012. https://www.cbsnews.com/news/michael-marin-former-wall-street-trader-took-cyanide-after-arson-conviction-says-autopsy/
Woodstock man at the center of “S-Town” podcast . Tuscaloosa News. March 28, 2017. http://www.tuscaloosanews.com/news/20170328/woodstock-man-at-center-of-s-town-podcast
Methods of Execution. Death Penalty Information Center. https://deathpenaltyinfo.org/methods-execution