Today, December 19, 2014, the United States Drug Enforcement
Administration (DEA) filed a notice of intent for placement of three new
synthetic cannabinoids into Schedule I of the Controlled Substance Act (CSA).
These three substances are:
AB-CHMINACA, AB-PINACA, and THJ-2201
All three of the substances have been discussed at one time
or another here on TDMTP and are suspected to be CB1/CB2 receptor agonists, but true pharmacological and toxicological evidence does not exist.
N-(1-amino-3-methyl-1-oxyobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide. The “alphabet
soup” name seems to reside in the following generic name: AminomethloxoButanePentylINdAzoleCarboxAmide. This synthetic cannabinoid
was first encountered in March 2013 (reported by the National Forensic Laboratory
Information System or NFLIS) and June 2013 (reported by the System to Retrieve
Information from Drug Evidence or STRIDE). States reporting detection of this
substance in products include AL, AR, AZ, CA, CO, CT, FL, GA, IA, ID, IL, IN,
KS, KY, LA, MA, MI, MN, MO, MS, ND, NE, NH, NJ, NV, NY, OH, OK, OR, PA, SC, TN,
TX, UT, VA, WA, WI, WV, and WY. From March 2013 to September 2014, there were 4
seizures of this compound (6 kg). Adverse effects from using the substance (as
well as AB-CHMINACA discussed below) were seizures and convulsions, unconsciousness
and coma, agitation, motor function loss, and respiratory issues. The DEA also
reports that there have been at least 3 documented deaths involving AB-PINACA.
Some literature references for AB-PINACA:
al. (2014) UPLC/ESI-MS/MS-based determination of metabolism of several new
illicit drugs, ADB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC, and Alpha-PVT, by
human liver microsome. Biomedical
Chromatography, 28, 831-838. PMID 24861751.
Thomsen et al. (2014) Synthetic cannabimimetic
agents metabolized by carboxylesterases. Drug
Testing and Analysis, Article in Press, doi: 10.1002/dta.1731, PMID
Shanks et al. (2014) “Case Reports: Fatalities
Associated with the Synthetic Cannabinoid, AB-PINACA”, Society of Forensic Toxicologists (SOFT)
annual meeting abstract proceedings, Grand Rapids, MI, 2014
N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamide. The “alphabet soup” name seems to reside in
the following generic name: AminomethloxoButaneCycloHexylMethylINdAzoleCarboxAmide. This synthetic cannabinoid was first
encountered in February 2014 (NFLIS) and March 2014 (STRIDE). States reporting
detection of this substance in products include AR, AZ, CA, CO, GA, IA, IN, KS,
KY, LA, MO, ND, NJ, OH, OK, PA, TN, TX, and WI. From February 2014 to September
2014, there were 17 seizures of this compound (15.825 kg). The DEA also reports
that there have been at least 4 documented deaths involving AB-CHMINACA.
A literature reference for AB-CHMINACA:
Hasegawa et al. (2014) Postmortem distribution of AB-CHMINACA, 5-fluoro-AMB,
and diphenidine in body fluids and solid tissues in a fatal poisoning case:
usefulness of adipose tissue for detection of the drugs in unchanged forms. Forensic Toxicology, Article in Press,
THJ-2201 is [1-(5-fluoropentyl)-1H-indazol-3-yl)naphthalene-1-yl)methanone.
This synthetic cannabinoid was first encountered in September 2013 (STRIDE) and
January 2014 (NFLIS). States reporting detection of this substance in products
include AR, AZ, CT, GA, IA, IL, IN, KS, KY, MN, MO, ND, NE, NH, NJ, OH, PA, TN,
and WI. From September 2013 to September 2014 there were 6 seizures of this
compound (5.5 kg). The DEA did not report any information on deaths associated
with this compound.
A literature reference for THJ-2201:
Shevyrin et al. (2014) 3-Naphthoylindazoles and 2-naphthoylbenzoimidazoles
as novel chemical groups of synthetic cannabinoids: chemical structure
elucidation, analytical characterists and identification of the first
representatives in smoke mixtures. Forensic
Science International, 242, 72-80. PMID 25036783.
So, now after legislation and a few rounds of emergency
scheduling, there are 25 synthetic
cannabinoid compounds explicitly listed as federally controlled Schedule I
AM2201, AM694, CP-47,497, CP-47,497 (C8), JWH-018/AM678, JWH-019,JWH-073, JWH-081, JWH-122, JWH-200, JWH-203, JWH-250, JWH-398, RCS-4/SR-19,RCS-8/SR-18
AKB48, UR144, XLR11
5F-PB-22, AB-FUBINACA, ADB-PINACA, PB-22
AB-CHMINACA, AB-PINACA, THJ-2201
Wonder what will be next? Maybe the AMB series?
We’ll see. As always, the beat goes on.