Saturday, May 21, 2016

More on W-18's pharmacology

Another update on Twitter by Dr. Bryan Roth from Roth Lab at UNC - Chapel Hill...









So, no predicted opioid activities again. Only histamine H3 receptor activity. And data will be posted on Bioarchivx sometime this coming week!

Ain't social media great?

7 comments:

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  2. How about nicotinic acetylcholine receptors as causes of or contributors to analgesic effects and toxicity? (Recall the non-opioid epibatidine active in the (non-specific) Straub tail test.)
    I have (intentionally?) stumbled upon a recent paper describing structure - insecticidal activity relationship studies on very close relatives of the W-x compounds.
    Yang et al: Design, synthesis, crystal structure, bioactivity, and molecular docking studies of novel sulfonylamidine-derived neonicotinoid analogs. Med Chem Res 23:5043 (2014)
    http://link.springer.com/article/10.1007%2Fs00044-014-1046-5

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  3. The W-18 is probably devoid of opioid activity. The "data" came from Canadian university group publication of their test results in mouse writhing and hot plate tests. It was never re-confirmed, and now it turns out to be just an artifact.

    These mouse pain perception tests can be easily skewed by any off-target central activity that makes the mouse incapacitated. In this case, histaminic activity-related drowsines

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  4. Posting this as warning im experiencing withdrawal from mdmb-chimica and i have stomach ulcers, and im terrified im n t gunna make it. My whole body feels like bag of fragile bones and muscle cramps wtf happened to jwh-018.

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    1. Er only gave me antibiotics and nausia medicine the worst part is the uncers i literally cant do anything

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    2. Er only gave me antibiotics and nausia medicine the worst part is the uncers i literally cant do anything

      Delete