Monday, March 2, 2015

Foxy's cousin, 5-MeO-MiPT

What did the Fox say? Well, we still aren't really sure.

I've viewed the arrest warrant application and affidavits (provided via the nice folks at Bluelight) that were filed in the Wesleyan University campus, Connecticut “Molly” overdoses.

According to these documents, some specimens confiscated by the authorities field tested positive for amphetamines, but these specimens were analyzed via the CT state crime laboratory and were reported as negative with the exception of a capsule that contained a white-colored powdery rock-like substance. This substance was previously identified as “Molly”. The specimen was identified as 5-Methoxy-N-methyl-N-isopropyltryptamine, otherwise known as 5-MeO-MiPT.
5-MeO-MiPT is a tryptamine substance that is used for its psychedelic and hallucinogenic properties. The substance is a 5-HT1A and 5-HT2A (serotonin) receptor agonist and acts as a serotonin-norepinephrine reuptake inhibitor (SNRI). It may also have monoamine oxidase inhibition (MAOI) activity. It is not considered a controlled substance at the Federal level in the United States, but may be considered a “controlled substance analog” as it is a very close derivative of the scheduled substance, 5-MeO-DiPT, which is known as "Foxy Methoxy" or "Foxy".
According to Alexander and Ann Shulgin’s book TiHKAL: The Continuation (which stands for Tryptamines I Have Known and Loved), the substance is active in 4-6 mg dosages. Commentary in TiHKAL after dosing with 6, 7, 10, and 12 mg oral dosages of the drug are interesting.
If you don't have access to TiHKAL, here are some direct experience quotes:
After a 6 mg oral dosage:



“One hour in and I felt turned on as if a wave passed over my body, and then the wave went back to the ocean, or wherever waves go. I was getting hungry but I didn’t want to go to the kitchen, as I didn’t want to interact with anyone I might encounter. What remained with me the longest was the awareness of vibrations, and what felt best was the stillness.
After a 7 mg oral dosage:



“In one hour I was in a marvelous, sexy place. Everything was shaded with eroticism. Sex was explosive, and in another three hours I was completely ready for the outside, public world.”

After a 10 mg oral dosage:



“Colors on the edges of the wiggles of the eye, a sort of Jessie Allen running design with color contrasts and sparkle. People’s faces were interesting, quite serious, and not completely friendly…this is a definite sense-distorter. I am not completely sure I like it.”

After a 12 mg oral dosage:



“…Warm was comfort and comfort was good. Warm led into a wonderful sexual turn on, where my entire body was alive and alert. This was one hour into the trip. This sexual turn-on was the feeling of a bud about to unfold into a full-blown, beautiful flower, which happened during love making.”

After a 12 mg oral dosage:



“…I have never experienced such an increase of the peristalsis process in moving the burrito through my colon and with each defecation I would become a little more turned on…”

After a 12 mg oral dosage:



“There was a very strange, almost paranoid session of listening to music, about an hour and a half into it…It turned out that I was wrong; the music was strange but of good quality. It was my interpretation that was screwed up.”

After a 12 mg oral dosage:



“My experience with this material was different in its action than anything I had tried in the past – it came on quicker but with much less intensity. I really enjoyed the mellowness, and it sort of waved in and out…”

After a 12 mg oral dosage:



“…Quickly aware and in the second half hour I rapidly shot up to a +++ in a very LSD-like manner, without the visuals. Time was quite slowed down during this come-on. Erotic world was fantastic, explosive, almost scary."
Overall, 5-MeO-DiPT is described by the Shulgins as being easily synthesized, having short lived effects (duration is 4-8 hours) and pretty high potency (4-12 mg oral dosage). Its phsyical side effects are "minimal", but it is a "mixed bag" in regards to its usefuless in experiences.


On a side note, Shulgin also includes a pretty funny story about the initial synthesis of 5-MeO-MiPT and its subsequent publication in literature with a missing co-author. Read it if you have the chance.

My thoughts on all of this?
No MDMA or methylone or other substance is reported as being found or confirmed by the CT state crime laboratory, which is interesting in of itself.
I wonder how much 5-MeO-MiPT was actually in this substance referenced in the documents? Due to the substance's higher potency, may this be a case of way, way too much drug being consumed at one time? MDMA is typically dosed in 50-100 or so mg tablet/capsules. And we see time and time again of large dosages being consumed unknowingly.
IF (and that’s a big IF as this is all speculation on my part) the drug that caused these overdoses was actually 5-MeO-MiPT, then what was the dosage consumed? 5 mg? 15 mg? 50 mg? 100 mg? The only effects described in the documents were "extremely ill", "very ill", "feel very weird", "out of it", "heavy', and "dissociated feeling". Vomiting, feeling hazy, and hallucinations were also mentioned.
It is also interesting, but not surprising (afterall this is a college campus), to note that many other prescription and nonprescription substances were found in the searched areas. These included alprazolam, bupropion, buspirone, cabergoline, carvedilol, coluracetam, dimethyltryptamine (DMT), donepezil, escitalopram, etizolam, hydroxyzine, linisopril, lioresal, methylphenidate, moclobemide, O-acetylpsilocin, olanzapine, oxiracetam, phenylpiracetam, propranolol, rasagiline, sulbutiamine, tamsufine, telmisartan, topiramate, trazodone, and valsartan. A rather eclectic and interesting mix of substances.

Doing a quick literature survey, it seems that there is a single case report from 2007  out of Japan that describes an intoxication after use of a product containing 60% methylone and 38% 5-MeO-MiPT. Not much else is out there in regards to toxicological profile of this substance.
As always, I'll wait to add to more thoughts at a later time when additional information is disclosed (if it ever is).

3 comments:

  1. I have heard that the risk of serotonin syndrome is increased and there is danger when mixing 5-meo-mipt with phenylethylamines.

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  2. I find it higgly unlikely that anyone is using lisinopril or valsartan for recreational purposes.

    ReplyDelete
  3. I find it higgly unlikely that anyone is using lisinopril or valsartan for recreational purposes.

    ReplyDelete