Friday, March 6, 2015

Case Report - Pentedrone and Alpha-PVP Associated Death

A Fatal Case of Pentedrone and α-Pyrrolidinovalerophenone Poisoning
Sykutera M, Cychowska M, and Bloch-Boguslawska E
Journal of Analytical Toxicology (2015) doi: 10.1093/jat/bkv011

This case was reported out of the Department of Forensic Medicine, Collegium Medicum of Nicolaus Copernicus University in Poland.
The case involved a 28 year old man who was a known user of “designer drugs” who was transported to the hospital while in asystole. A white powdery substance in a bag labeled “α-PVP” and material safety data sheets (MSDS) for alpha-PVP and pentedrone were retrieved from his jacket pocket.

Resuscitative attempts failed and he was pronounced deceased 30 minutes after arrival. Upon autopsy, pulmonary edema and atherosclerotic lesions of the arteries was documented. Microscopic evaluation of tissues revealed “chronic changes in the heart”, which was defined as “uneven staining pattern of the myocardium, fragmentation and waviness of fibers, perivascular connective tissue growth, intramuscular fibrosis and scarring, disintegration of cardiomyocytes, nuclear disintegration, loss of cross-striations , and thickening of blood vessel walls”. The presence of “hemosiderin-laden pulmonary macrophages” were also observed.

Femoral blood was positive for alpha-PVP (901 ng/mL) and pentedrone (8,794 ng/mL). Liver was positive for alpha-PVP (2,610 ng/g) and pentedrone (100,044 ng/g). Kidney was positive for alpha-PVP (462 ng/mL) and pentedrone (22,102 ng/mL). Brain was positive for alpha-PVP (120 ng/g) and pentedrone (13,48 ng/g). Gastric contents were positive for alpha-PVP (4,190 ng/g) and pentedrone (500,534 ng/g). Cause of death was multiple drug toxicity associated with alpha-PVP and pentedrone use.

We have talked about alpha-PVP before on this blog in regards to a generic named street drug, gravel.

Gravel: human sacrifice, dogs and cats living together...mass hysteria?

Both pentedrone and alpha-PVP are currently Schedule I controlled substances in the USA.


  1. Really much unknown information about the Pentedrone and Alpha-PVP. And I think may be few peoples are aware about this. Though MSDS that given with this chemical by authorizations as "ICSDS" can aware users about this.

  2. My brother died aged 32 snorting this. Pentedrone found on toxicology. But no cause of death. Undetermined. Odd the comment above on 13/4/2015 was the last day I saw him alive. He was found cold and stiff at lunchtime on the 15/4/2015. This shit is fucking dangerous

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