Friday, April 29, 2016

DEA Schedules AH-7921

On April 14, 2016, the US DEA placed the opioid research chemical AH-7921 into Schedule I of the Controlled Substances Act. This move surprised me because I hadn't heard anything about it, but it's expected.

You can find the DEA final order here.

Now, with this substance scheduled, will U-47700 be considered a Controlled Substance Analog under the Analog Enforcement Act?

I'm sure it will be.


  1. I'm sure it cannot be. On one hand, the 3,4-dichlorobenzamide moiety is present in other bioactive substances such as the non-opioid loxiglumide. On the other, the a vicinal diamine moiety, that is 1,2-diaminocyclohexane, is definitely distinct from the geminally disubstituted cyclohexane group present not only in AH-7921 (a mu opioid receptor liggand) but also in other related opioids such as U-50488 acting on the kappa opioid receptors (causing disphoria rather than euphoria). These are, I believe, strong arguments against chemical or biological similarity.

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