Tuesday, February 3, 2015

New synthetic cannabinoids in Louisiana - January 2015

The state of Louisiana recently controlled a few newer synthetic cannabinoid compounds that their state crime labs have detected in newer herbal incense and potpourri products.

These are MDMB-CHMICA, PX1, and PX2.

MDMB-CHMICA is methyl (S)-​2-​(1-​(cyclohexylmethyl)-​1H-​indole-​3-​carboxamido)-​3,​3-​dimethylbutanoate. Chemical formula is C23H32N2O3.

PX1 is (S)-​N-​(1-​amino-​1-​oxo-​3-​phenylpropan-​2-​yl)-​1-​(5-​fluoropentyl)-​1H-​indole-​3-​carboxamide. Chemical formula is C23H26FN3O2. Alternate names for PX1 are SRF-30 and 5F-APP-PICA.

PX2 is (R)-​N-​(1-​amino-​1-​oxo-​3-​phenylpropan-​2-​yl)-​1-​(5-​fluoropentyl)-​1H-​indazole-​3-​carboxamide. Chemical formula is C22H25FN4O2. Alternate names for PX2 are FU-PX and 5F-APP-PINACA.

The compounds are suspected to be a synthetic cannabinoid receptor 1 and 2 agonists, but as we've discussed for the vast majority of these compounds, the human pharmacology and toxicology is unknown at this time.

The article linked above mentions that they have been suspected in hospitalizations and deaths in Louisiana, but I know of no such lab that does testing for these in a biological (blood or urine) matrix.


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