Due to some recent illnesses and detections in herbal incense products (named Train Wreck 2 and Kali Berry 2), two newer generation synthetic cannabinoids have been added to the controlled substances list by the state of Louisiana. These are 5F-AMB and FUB-AMB.
The AMB series of compounds can be considered derivatives of the earlier AB-INACA series of synthetic cannabinoids. AMB compounds differ from the AB-INACA substances by a replacement of a primary amine with methoxy group. This change leads to a moiety structurally based off the amino acid, valine, also known as 2-amino-3-methylbutanoic acid. Valine is not produced by the human body and must be ingested via the diet.
Indole based derivatives also exist. Two of these are named MMB018 and MMB2201.
So, what's all of this mean? I don't know. And I doubt any other toxicologist or chemist knows either. Again, as with all new emerging substances, this new series has an unknown pharmacological and toxicological profile. Simply, it is just more unknown entities to add to the rapidly growing heap of unknowns.
I'll end with a question and I welcome your responses...would we be in this cat and mouse game between manufacturers and legislators if we had approached the first wave of JWH compounds (JWH-018, JWH-073, JWH-200) somewhat differently back in 2010-2011?