The outline of topics for this lecture included:
Fentanyl, Fentanyl Analogs, and Designer Opioids
- Sliding scale of harm
- Water
- SSRI antidepressants
- Benzodiazepines
- Tricyclic antidepressants
- Barbiturates
- Opiates / Opioids
- Opioid Deaths in the USA (Pre-2014/2015)
- 2000 - 2014 data
- Opioid analgesic deaths continue to rise
- Surge in deaths, two trends
- Double trouble: heroin and fentanyl
- Heroin
- History
- Chemistry
- Pharmacology
- Metabolism
- Forms of the product
- NFLIS data, 2001 - 2016
- Fentanyl
- History
- Chemistry
- Pharmacology
- Metabolism
- Forms of the product (licit vs. illicit)
- Death of Prince
- NFLIS data, 2001 - 2015
- NFLIS data, 2013 - 2015
- NFLIS data, 2016
- NY Times report on trends in US overdose deaths, 2017
- Fentanyl Analogs
- What are they? Where do they come from?
- How many compounds exist?
- DEA scheduling actions, 2015 - 2017
- DEA Emerging Threats Reports, 2017
- Overdoses, hospitalizations, and reported deaths in media
- Analyte Specific Looks
- 3-methylfentanyl (cis/trans)
- Acetylfentanyl
- Furanylfentanyl
- Acrylfentanyl
- Carfentanil
- Designer Opioids
- Opioid research chemicals
- U47700
- Death of Prince
- AH7921
- MT-45
- Analytical Methods
- Method development
- Method validation
- Organic extraction
- Instrumental analysis via LC-MS/MS
- Prevalence
- What drugs have been detected?
- How prevalent are they?
- What locations are they found?
- Special look at Carfentanil detections
- Postmortem Case Studies
- Case 1 (Information Withheld)
- Case 2 (Information Withheld)
- Case 3 (Information Withheld)
- Case 4 (Information Withheld)
- Case 5 (Information Withheld)
- Case 6 (Information Withheld)
- Case 7 (Information Withheld)
- Case 8 (Information Withheld)
- Testing for Fentanyl Analogs and Designer Opioids vs. A Fishing Expedition
- Conclusions
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