How about nicotinic acetylcholine receptors as causes of or contributors to analgesic effects and toxicity? (Recall the non-opioid epibatidine active in the (non-specific) Straub tail test.) I have (intentionally?) stumbled upon a recent paper describing structure - insecticidal activity relationship studies on very close relatives of the W-x compounds. Yang et al: Design, synthesis, crystal structure, bioactivity, and molecular docking studies of novel sulfonylamidine-derived neonicotinoid analogs. Med Chem Res 23:5043 (2014) http://link.springer.com/article/10.1007%2Fs00044-014-1046-5
The W-18 is probably devoid of opioid activity. The "data" came from Canadian university group publication of their test results in mouse writhing and hot plate tests. It was never re-confirmed, and now it turns out to be just an artifact.
These mouse pain perception tests can be easily skewed by any off-target central activity that makes the mouse incapacitated. In this case, histaminic activity-related drowsines
Posting this as warning im experiencing withdrawal from mdmb-chimica and i have stomach ulcers, and im terrified im n t gunna make it. My whole body feels like bag of fragile bones and muscle cramps wtf happened to jwh-018.
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ReplyDeleteHow about nicotinic acetylcholine receptors as causes of or contributors to analgesic effects and toxicity? (Recall the non-opioid epibatidine active in the (non-specific) Straub tail test.)
ReplyDeleteI have (intentionally?) stumbled upon a recent paper describing structure - insecticidal activity relationship studies on very close relatives of the W-x compounds.
Yang et al: Design, synthesis, crystal structure, bioactivity, and molecular docking studies of novel sulfonylamidine-derived neonicotinoid analogs. Med Chem Res 23:5043 (2014)
http://link.springer.com/article/10.1007%2Fs00044-014-1046-5
The W-18 is probably devoid of opioid activity. The "data" came from Canadian university group publication of their test results in mouse writhing and hot plate tests. It was never re-confirmed, and now it turns out to be just an artifact.
ReplyDeleteThese mouse pain perception tests can be easily skewed by any off-target central activity that makes the mouse incapacitated. In this case, histaminic activity-related drowsines
Posting this as warning im experiencing withdrawal from mdmb-chimica and i have stomach ulcers, and im terrified im n t gunna make it. My whole body feels like bag of fragile bones and muscle cramps wtf happened to jwh-018.
ReplyDeleteEr only gave me antibiotics and nausia medicine the worst part is the uncers i literally cant do anything
DeleteEr only gave me antibiotics and nausia medicine the worst part is the uncers i literally cant do anything
Delete